It began with an Institute of Computer Science and Technology founded in 1985 by Prof. P. Murugesan. At that time, his very purpose of starting that institute was to introduce Computer Education for the first time in Thanjavur District. In 1988, the Institute got affiliation from Bharathidasan University to offer Post Graduate Diploma Programme in Computer Applications. Since then, it has added Arts and Science College, College of Engineering and Technology, College of Education, Research Institution, and a Polytechnic College. There are campuses in Trichy, Kumbakonam, Puducherry, Chennai, and Madurai.

Degrees are offered in Engineering, Arts & Science, Education, Pharmacy, Management, and Technology, including some at the Ph.D. level.

From the day of its establishment it has been the philosophy of the PRIST University to provide high quality educational programmes specially designed for young minds who seek knowledge skills, and also wish to perceive success in the age of knowledge.

A Magnifying personality with undaunted faith and indomitable courage, striving decade after decade for the cause of social reform, humanism and education – this description aptly fits the chancellor Prof.P.Murugesan- The man  with the Midas touch now extends his hands for a Medical Institution

Now, PRIST University- goes for a Mammoth Endeover – A Medical College Hospital to care to the poor, to reach the unreachable and to deliver quality medical and paramedical education.

The new Medical venture of PRIST is named as PRIMS (Ponnaiyah Ramajayam Institute of Medical Sciences) situated in Nallur, Next Mamallapuram, ECR,  Chennai- 603 102 . PRIMS is affiliated to Tamil Nadu Dr. MGR Medical University. In a greeny land scape near the exotic Mamallapuram lies the massive buildings of PRIMS.